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Mode of action of hydroxychloroquine in RA—evidence of an inhibitory effect on toll-like receptor...
Nature· 1 day agoAntimalarial drugs have been used for many years to treat rheumatic diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The two most commonly used antimalarial ...
News Analysis - Nature Reviews Drug Discovery
Nature· 1 day agoUnderstandably, obviousness comes up frequently in disputes between innovator companies and generics manufacturers who look to market generics in light of the innovator patent being obvious, ...
Stalemate - Nature Reviews Cancer
Nature· 1 day agoThe immune system has crucial roles in shaping cancer development: it can detect early lesions through immunosurveillance and eliminate them, it is thought to maintain tumours in a state of ...
A sweet sabre promotes cell invasion - Nature Reviews Cancer
Nature· 1 day agoUsing a new CSE-specific antibody, Sugahara et al. detected CSE in various mouse models of spontanous pancreatic cancer. Cleavage of the extracellular domain of CD44 by metalloproteinases ...
The plasticity of chromatin - Nature Reviews Neuroscience
Nature· 1 day agoGuan et al. cultured Aplysia sensory neurons so that their efferent process bifurcated and contacted two separate postsynaptic motor neurons, making it possible to stimulate the two branches ...
Specialty pharmaceuticals to provide majority of sales by 2012 - Nature Reviews Drug Discovery
Nature· 1 day agoLarge pharmaceutical companies have increasingly been pursuing specialty pharmaceuticals — that is, drugs prescribed primarily by specialists rather than general practitioners (GPs). To investigate ...
Firms chase diabetic inflammation with anti-IL-1β antibodies - Nature Biotechnology
Nature· 1 day agoJuerg Tschopp, of the University of Lausanne, Switzerland, and his colleagues propose a central role for the NLRP3 (NOD-like receptor family, pryin domain containing 3) inflammasome—a multiprotein ...
GMP cell lines to order - Nature Biotechnology
Nature· 1 day agoEden Biodesign and Millipore have struck a deal to offer a service of mammalian cell lines on demand for companies developing antibodies and protein therapeutics. The collaboration marries Millipore's ...
Landmark approval for Dendreon's cancer vaccine - Nature Biotechnology
Nature· 1 day agoThe April 29 approval of Seattle-based Dendreon's prostate cancer vaccine, Provenge (sipuleucel-T), is being hailed as a victory for cancer immunotherapy. For Dendreon, the US Food and Drug ...
Homologous Species Neoplastic Antibodies - Nature
Nature· 1 day agoPrehn and Main1, in a review of the subject, state that the demonstration of circulating cytotoxins is much simpler when heterologous tissue transplants are used as antigens than when homologous ...
