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Antigen processing by the proteasome - Nature Reviews Molecular Cell Biology
Nature· 4 days agoThe proteasome is an essential part of our immune surveillance mechanisms: by generating peptides from intracellular antigens it provides peptides that are then 'presented ...
Tapping into MAGE potential to develop next-generation cancer therapies
Nature· 4 days agoBiotech company APO-T is developing bispecific T cell engagers (BiTEs) that facilitate the attraction of immune effector cells exclusively to cancer sites by targeting cancer ...
Glycostem launches pivotal oncology trial with evolved naked natural killer cells
Nature· 4 days agoNK cells are part of the immune system, and oNKord, Glycostem’s technology platform, uses stem cells harvested from umbilical cord blood (UCB).
Opinion | John Roberts Makes His Bid for Infamy
New York Times· 4 days agoThe most important takeaway from the Supreme Court’s decision in Trump v. United States is that John Roberts, with the approval of his Republican...
Superantigen antagonist protects against lethal shock and defines a new domain for T-cell activation...
Nature· 4 days agoSuperantigens trigger an excessive cellular immune response, leading to toxic shock. We have designed a peptide antagonist that inhibits superantigen-induced expression of ...
An Alpha2-globulin Component Absent in Serum of Human Foetuses - Nature
Nature· 4 days agoWHEN studying specific antigenic properties of sweat proteins using rabbit immune serum against sweat proteins, we have found sweat protein to consist of several components ...
Augmented intelligence at the service of personalised medicine: how artificial intelligence is...
Nature· 4 days agoThe traditional drug discovery and development process contends with a high failure rate of clinical trials at phase 2 and 3 as patients do not respond the same way to a given treatment. MIMs ...
Redefining cancer therapy with photoimmunotherapy
Nature· 4 days agoClinical trials are under way for a new antibody-based anticancer platform called photoimmunotherapy (PIT), which has shown promise in selectively...
ResponderID: the future of predictive biomarker discovery is now
Nature· 4 days agoThe promise of targeted cancer therapies relies on ensuring that they reach the right patients: those with the tumor-associated biological changes targeted by a given therapeutic. Achieving ...
Opinion | The Deep Source of Trump’s Appeal
New York Times· 4 days agoA group of Democratic officials and union leaders told journalists that Donald Trump was competitive in New York State. In 2020, Joe Biden won New York...