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β-amyloid monomer scavenging by an anticalin protein prevents neuronal hyperactivity in mouse models...
Nature· 2 days agoβ-amyloid (Aβ)-dependent neuronal hyperactivity is an early marker of Alzheimer’s Disease (AD). Here, the authors report that scavenging Aβ monomers by an Aβ-binding anticalin protein blocks ...
Liver X receptor inverse agonist SR9243 attenuates rheumatoid arthritis via modulating glycolytic...
Nature· 2 days agoLiver X receptors (LXRs) which link lipid metabolism and inflammation, were overexpressed in experimental rheumatoid arthritis (RA) rats as observed in our previous studies, while suppression ...
Spores of Clostridioides difficile are toxin delivery vehicles - Communications Biology
Nature· 2 days agoThis study shows that the genes coding for the two main toxins produced by Clostridioides difficile are expressed during sporulation and that the toxins associate with the mature spores, which have a cytopathic effect on human intestinal cell lines.
Graphene oxide electrodes enable electrical stimulation of distinct calcium signalling in brain...
Nature· 2 days agoElectrical stimulation of astrocytes using electrodes coated with graphene oxide and reduced graphene oxide can be used to trigger specific calcium signals.
Beloved WWE superstar 'gone for some time' after surgery for brutal injuries
Metro· 3 days agoHe continued: ‘I’m in good spirits and looking forward to seeing you all again soon, lots of love, b...
Ireland U20 fall to Italy defeat despite late brace of tries from Kelly Burke
Irish Independent· 3 days agoDespite replacement hooker Kelly Burke grabbing a late brace of tries, the Ireland U20s fell to a...
Wimbledon day 8: Will Rybakina break cycle? Did we see the most chaotic match-up?
New York Times· 3 days agoTo start Wimbledon's second week: Elena Rybakina's limelight and chaos on Court One
Ireland under-20s square off against Australia knowing avoiding defeat will secure top spot in Pool ...
The Irish Times· 4 days agoWillie Faloon’s side find themselves in this advantageous position by virtue of Italy’s 17-12...
A draw against Australia enough for Irish U-20s to make World Championship semis, but a loss would...
Irish Independent· 4 days agoAustralia’s surprising 17-12 loss to Italy last Thursday raised a few eyebrows, and while Ireland...
Mackin leads Armagh to All-Ireland semi-finals
GAA Football & Hurling· 4 days agoBlaithin Mackin led the way as Armagh advanced to the semi-finals of the TG4 All-Ireland SFC with a decisive victory at BOX-IT Athletic Grounds. Armagh led by 1-6 to 0-3 at the break, having ...