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Olfactory ensheathing cell transplantation as a strategy for spinal cord repair—what can it achieve?...
Nature· 4 days agoNumerous lines of evidence from animal studies indicate that transplants of olfactory ensheathing cells—glial cells derived from the olfactory system—can promote functional recovery in the injured ...
Detecting genomic islands using bioinformatics approaches - Nature Reviews Microbiology
Nature· 4 days agoThe identification of genomic islands in bacterial genomes is becoming increasingly important. In this Analysis article, Fiona Brinkman and colleagues look at the limitations and benefits of ...
Thymic lymphoproliferative disease after successful correction of CD40 ligand deficiency by gene...
Nature· 4 days agoInherited deficiency of the CD40 ligand (X-linked hyper-IgM syndrome) is characterized by failure of immunoglobulin isotype switching and severe defects of cell-mediated immunity. To test the ...
Fabrication of ECM protein coated hollow collagen channels to study peripheral nerve regeneration -...
Nature· 4 days agoPeripheral nerve injury is a prevalent clinical problem that often leads to lifelong disability and reduced quality of life. Although peripheral nerves can regenerate, recovery after severe ...
Leukaemogenesis: more than mutant genes - Nature Reviews Cancer
Nature· 4 days agoEpigenetic modifications, including DNA methylation and histone modifications, as well as microRNAs, contribute to the development of acute leukaemias. This Review describes the current understanding ...
Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute...
Nature· 4 days agoFamilial platelet disorder with predisposition to acute myelogenous leukaemia (FPD/AML, MIM 601399) is an autosomal dominant disorder characterized by qualitative and quantitative platelet defects ...
Lamotrigine Is Neuroprotective in the Energy Deficiency Model of MPTP Intoxicated Mice - Pediatric...
Nature· 4 days agoThe 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) inhibits the mitochondrial complex I of the respiratory chain. This results in ATP and ion homeostasis disturbances, which lead to selective ...
Chronic systemic pesticide exposure reproduces features of Parkinson's disease - Nature Neuroscience
Nature· 4 days agoThe cause of Parkinson's disease (PD) is unknown, but epidemiological studies suggest an association with pesticides and other environmental toxins, and biochemical studies implicate a systemic ...
Phenylethanolamines inhibit NMDA receptors by enhancing proton inhibition - Nature Neuroscience
Nature· 4 days agoThe phenylethanolamines, ifenprodil and CP-101,606, are NMDA receptor antagonists with promising neuroprotective properties. In recombinant NMDA receptors expressed in Xenopus oocytes, we found ...
Generation of cerebellar granule neurons in vivo by transplantation of BMP-treated neural progenitor...
Nature· 4 days agoCerebellar granule neurons, the most abundant class of CNS neurons, have a critical role in cerebellar function. Granule neurons are generated at the dorsal border of the mesencephalon and metencephalon ...