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Thymic lymphoproliferative disease after successful correction of CD40 ligand deficiency by gene...
Nature· 4 days agoInherited deficiency of the CD40 ligand (X-linked hyper-IgM syndrome) is characterized by failure of immunoglobulin isotype switching and severe defects of cell-mediated immunity. To test the ...
Fabrication of ECM protein coated hollow collagen channels to study peripheral nerve regeneration -...
Nature· 4 days agoPeripheral nerve injury is a prevalent clinical problem that often leads to lifelong disability and reduced quality of life. Although peripheral nerves can regenerate, recovery after severe ...
Leukaemogenesis: more than mutant genes - Nature Reviews Cancer
Nature· 4 days agoEpigenetic modifications, including DNA methylation and histone modifications, as well as microRNAs, contribute to the development of acute leukaemias. This Review describes the current understanding ...
Cytotoxicity Is Predicted by Unbound and Not Total Bilirubin Concentration - Pediatric Research
Nature· 4 days agoAlthough it has been suggested that the unbound, free, (Bf) rather than total (BT) bilirubin level correlates with cell toxicity, direct experimental evidence supporting this conclusion is limited ...
A textbook for all seasons - Nature Genetics
Nature· 8 hours agoA textbook for all seasons. Nat Genet 39 , 1179 (2007). https://doi.org/10.1038/ng1007...
Lamotrigine Is Neuroprotective in the Energy Deficiency Model of MPTP Intoxicated Mice - Pediatric...
Nature· 4 days agoThe 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) inhibits the mitochondrial complex I of the respiratory chain. This results in ATP and ion homeostasis disturbances, which lead to selective ...
Generation of cerebellar granule neurons in vivo by transplantation of BMP-treated neural progenitor...
Nature· 4 days agoCerebellar granule neurons, the most abundant class of CNS neurons, have a critical role in cerebellar function. Granule neurons are generated at the dorsal border of the mesencephalon and metencephalon ...
Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes - Nature...
Nature· 4 days agoLow oxygen tension influences tumor progression by enhancing angiogenesis; and histone deacetylases (HDAC) are implicated in alteration of chromatin assembly and tumorigenesis. Here we show ...
Hypoxia Induces Alteration of Bone Morphogenetic Protein Receptor Signaling in Pulmonary Artery...
Nature· 4 days agoReduced expression of bone morphogenetic protein receptors (BMPR) has been implicated in the pathogenesis of pulmonary hypertension (PH), but changes in the intracellular signaling pathway of ...
Eigen-entropy based time series signatures to support multivariate time series classification -...
Nature· 4 days agoMost current algorithms for multivariate time series classification tend to overlook the correlations between time series of different variables. In this research, we propose a framework that ...