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Lamotrigine Is Neuroprotective in the Energy Deficiency Model of MPTP Intoxicated Mice - Pediatric...
Nature· 4 days agoThe 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) inhibits the mitochondrial complex I of the respiratory chain. This results in ATP and ion homeostasis disturbances, which lead to selective ...
Chronic systemic pesticide exposure reproduces features of Parkinson's disease - Nature Neuroscience
Nature· 4 days agoThe cause of Parkinson's disease (PD) is unknown, but epidemiological studies suggest an association with pesticides and other environmental toxins, and biochemical studies implicate a systemic ...
Phenylethanolamines inhibit NMDA receptors by enhancing proton inhibition - Nature Neuroscience
Nature· 4 days agoThe phenylethanolamines, ifenprodil and CP-101,606, are NMDA receptor antagonists with promising neuroprotective properties. In recombinant NMDA receptors expressed in Xenopus oocytes, we found ...
Generation of cerebellar granule neurons in vivo by transplantation of BMP-treated neural progenitor...
Nature· 4 days agoCerebellar granule neurons, the most abundant class of CNS neurons, have a critical role in cerebellar function. Granule neurons are generated at the dorsal border of the mesencephalon and metencephalon ...
Hypoxia Induces Alteration of Bone Morphogenetic Protein Receptor Signaling in Pulmonary Artery...
Nature· 4 days agoReduced expression of bone morphogenetic protein receptors (BMPR) has been implicated in the pathogenesis of pulmonary hypertension (PH), but changes in the intracellular signaling pathway of ...
Eigen-entropy based time series signatures to support multivariate time series classification -...
Nature· 4 days agoMost current algorithms for multivariate time series classification tend to overlook the correlations between time series of different variables. In this research, we propose a framework that ...
Cardiac Ion Channel Gene Mutations in Sudden Infant Death Syndrome - Pediatric Research
Nature· 4 days agoSudden infant death syndrome (SIDS) is multifactorial and may result from the interaction of a number of environmental, genetic, and developmental factors. We studied three major genes causing ...
The Role of Microbes in Developmental Immunologic Programming - Pediatric Research
Nature· 4 days agoThe role of microorganisms in the gastrointestinal tract has undergone significant modification in the past few decades with new observations from clinical, epidemiologic, and basic science ...
Revealing new pathways for the reaction of Criegee intermediate CH2OO with SO2 - Communications...
Nature· 3 days agoCriegee intermediates such as CH2OO play an important role in tropospheric oxidation models through their reactions with atmospheric trace chemicals. Here, the authors develop a global full-dimensional ...
GM plants to be patented - Nature Biotechnology
Nature· 3 hours agoGM plants to be patented. Nat Biotechnol 18 , 131 (2000). https://doi.org/10.1038...