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Rap1 signalling: adhering to new models - Nature Reviews Molecular Cell Biology
Nature· 3 days agoRas-like GTPases are ubiquitously expressed, evolutionarily conserved molecular switches that couple extracellular signals to various cellular responses. Rap1, the closest relative of Ras, has ...
Mechanisms of transcriptional memory - Nature Reviews Molecular Cell Biology
Nature· 3 days agoHow can the same gene remember that it is 'off' in one cell lineage and 'on' in another? Studies of how homeotic genes are regulated in Drosophila melanogaster have uncovered a transcriptional ...
Regulation of ion transport proteins by membrane phosphoinositides - Nature Reviews Neuroscience
Nature· 3 days agoMembrane phosphoinositides are important for generating key intracellular second messengers and are also able to directly regulate the activity of membrane proteins. Gamper and Shapiro discuss ...
Three ways to make a vesicle - Nature Reviews Molecular Cell Biology
Nature· 3 days agoCargo molecules have to be included in carrier vesicles of different forms and sizes to be transported between organelles. During this process, a limited set of proteins, including the coat ...
Neuroprotective gene therapy against acute neurological insults - Nature Reviews Neuroscience
Nature· 3 days agoIn recent years, there has been tremendous progress in uncovering the molecular, cellular and systemic factors that give rise to neuronal death following acute neurological insults. This has ...
A point mutation in CD28 distinguishes proliferative signals from survival signals - Nature...
Nature· 3 days agoUpon interaction with its ligand, B7, CD28 becomes phosphorylated on tyrosines. One tyrosine in particular (Y170 in mouse CD28, Y173 in human CD28) has received much attention. This is because ...
Studies on somatic recombination in dikaryons of Schizophyllum commune - Heredity
Nature· 3 days agoBuller, A H R. 1931. Researches on Fungi, IV. Longmans Green & Co., London. Google Scholar Crowe, L K. 1960. The exchange of genes between nuclei of a dikaryon. Heredity, 15, 397–405.Article
Hematopoiesis in Regenerated Bone Marrow Within Hydroxyapatite Scaffold - Pediatric Research
Nature· 3 days agoWe examined whether regenerated bone marrow (BM) with BM-derived stromal cells (BMSCs) on hydroxyapatite (HA) scaffolds can reconstitute the functional niche. Ly5.2 BMSCs on HA scaffolds were ...
Maternal Stress During Pregnancy Predisposes for Iron Deficiency in Infant Monkeys Impacting Innate...
Nature· 3 days agoThe influence of maternal stress during pregnancy on the postpartum iron status and immune maturation of infants was investigated in a nonhuman primate model. Forty infant rhesus monkeys were ...
Hypoxia Induces Alteration of Bone Morphogenetic Protein Receptor Signaling in Pulmonary Artery...
Nature· 3 days agoReduced expression of bone morphogenetic protein receptors (BMPR) has been implicated in the pathogenesis of pulmonary hypertension (PH), but changes in the intracellular signaling pathway of ...