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A type II phosphatidylinositol-4-kinase coordinates sorting of cargo polarizing by endocytic...
Nature· 3 days agoThe Golgi-associated phosphatidylinositol-4-kinase AnLsb6 in Aspergillus nidulans may have adopted functions of the missing Pik1p homologue in Eurotiomycetes.
Can landscape ecology untangle the complexity of antibiotic resistance? - Nature Reviews...
Nature· 3 days agoThe field of landscape ecology links the biotic and abiotic factors of an ecosystem. In this Opinion article, the authors argue that using the tools of landscape ecology would improve the accuracy of ecological studies of antibiotic resistance.
Epigenetic control of neural precursor cell fate during development - Nature Reviews Neuroscience
Nature· 3 days agoUnderstanding the molecular basis of a cell's differentiation capacity will greatly aid attempts to use stem cells for therapeutic purposes. In this Review, Hirabayashi and Gotoh discuss the ...
Multicenter proteome-wide Mendelian randomization study identifies causal plasma proteins in...
Nature· 2 days agoThis study suggests that the circulating proteins ASIP, KRT5, CTSS, and TNFSF8 are causally associated with melanoma and non-melanoma skin cancer-related traits through a multicenter Mendelian randomization.
Eigen-entropy based time series signatures to support multivariate time series classification -...
Nature· 3 days agoMost current algorithms for multivariate time series classification tend to overlook the correlations between time series of different variables. In this research, we propose a framework that ...
Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute...
Nature· 3 days agoFamilial platelet disorder with predisposition to acute myelogenous leukaemia (FPD/AML, MIM 601399) is an autosomal dominant disorder characterized by qualitative and quantitative platelet defects ...
Cytotoxicity Is Predicted by Unbound and Not Total Bilirubin Concentration - Pediatric Research
Nature· 3 days agoAlthough it has been suggested that the unbound, free, (Bf) rather than total (BT) bilirubin level correlates with cell toxicity, direct experimental evidence supporting this conclusion is limited ...
A weak signal for strong responses: interferon-alpha/beta revisited - Nature Reviews Molecular Cell...
Nature· 3 days agoBiological systems have acquired adaptability and robustness against rapid environmental changes. A typical example is the immune system, which eradicates invading pathogens such as viruses.
New Approaches to Neuroprotection in Infant Heart Surgery - Pediatric Research
Nature· 3 days agoAdvances in surgical techniques and perioperative management have led to dramatic improvements in outcomes for children with complex congenital heart disease (CHD). As the number of survivors ...
The Probiotic Lactobacillus GG may Augment Intestinal Host Defense by Regulating Apoptosis and...
Nature· 3 days agoNecrotizing enterocolitis (NEC) remains a leading cause of morbidity and mortality in preterm infants. Although its pathogenesis is poorly understood, inappropriate apoptosis of the mucosal ...