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Mammalian cell display with automated oligo design and library assembly allows for rapid residue...
Nature· 4 days agoUsing a new method for rapid, residue-level epitope determination combining flow cytometry and surface displayed alanine substitution variants the authors determined the epitopes of three new antibodies binding the SARS-CoV-2 Spike protein.
The ACE1 secondary metabolite gene cluster is a pathogenicity factor of wheat blast fungus -...
Nature· 3 days agoMolecular analyses suggest that a blast resistance gene already defeated in rice may be revived as a durable resistance gene in wheat by targeting ACE1, a pathogenicity factor of the wheat blast fungus.
Spatially resolved imaging of human macular capillaries using adaptive optics-enhanced optical...
Nature· 2 days agoDocumenting the organization of the retinal capillaries is of importance to understand the visual consequences of vascular diseases which may differentially affect the microvascular layers.
Neuroscientists must not be afraid to study religion
Nature· 5 days agoScientists interested in the brain have tended to avoid studying religion or spirituality for fear of being seen as unscientific. That needs to change.
Chain Saws Were Invented to Help in Childbirth?
Snopes via Yahoo News UK· 12 hours agoHawk, Alan J. "ArtiFacts: Bernhard Heine's Osteotome." Clinical Orthopaedics and Related Research, vol. 474, no. 5, May 2016, pp. 1108–09. PubMed...
A CRISPR/Cas9 screen in embryonic stem cells reveals that Mdm2 regulates totipotency exit -...
Nature· 4 days agoA CRISPR/Cas9 screen identities regulators about the transition of pluripotency to totipotency and revealed Mdm2 as a significant negative regulator of totipotency.
Informed proxy consent for ancient DNA research - Communications Biology
Nature· 3 days agoEmbracing the underlying principles and processes of informed proxy consent or relational autonomy consent in human ancient DNA research can transform research.
Flexible adaptation of task-positive brain networks predicts efficiency of evidence accumulation -...
Nature· 5 days agoAnalyses of fMRI data across two large samples show that people’s cognitive efficiency, as measured by a computational model, is strongly related to the degree to which brain networks involved in cognitive control adapt to task difficulty.
RNA demethylase FTO participates in malignant progression of gastric cancer by regulating...
Nature· 5 days agoRNA demethylase FTO promotes gastric cancer tumorigenesis and progression via the SP1-AURKB-ATM signaling pathway, shedding new light on the diagnoses and treatments for gastric cancer patients.
Structural and functional insights underlying recognition of histidine phosphotransfer protein in...
Nature· 3 days agoStudies on the phosphorelay mechanism from receiver domains of fungal hybrid histidine kinases to HPt from Chaetomium thermophilum, including from Candida albicans, suggest low affinity for complex formation and absence of a Leu-Thr switch.