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Integrative analysis of genomic and epigenomic regulation reveals miRNA mediated tumor heterogeneity...
Nature· 3 days agoA miRNA multi-omics study reveals not only mechanisms for miRNA dysregulation, but also the tumor heterogeneity and immunological diversity within low grade glioma, and presents better prognostic value than traditional molecular markers.
Actomyosin organelle functions of SPIRE actin nucleators precede animal evolution - Communications...
Nature· 16 hours agoGenome analysis and molecular cell biology studies indicate that SPIRE actin nucleators originated in unicellular ancestors of animals, providing an actin-myosin driven exocytic transport mechanism that may have contributed to animal evolution.
Molting in early Cambrian armored lobopodians - Communications Biology
Nature· 4 days agoThis paper presents exceptionally preserved fossils from the early Cambrian that show how molting occurred in some of the very earliest arthropod relatives, a trait which enabled continuous growth in animals with hard exoskeletons.
Structural and functional insights underlying recognition of histidine phosphotransfer protein in...
Nature· 5 days agoStudies on the phosphorelay mechanism from receiver domains of fungal hybrid histidine kinases to HPt from Chaetomium thermophilum, including from Candida albicans, suggest low affinity for complex formation and absence of a Leu-Thr switch.
A CRISPR/Cas9 screen in embryonic stem cells reveals that Mdm2 regulates totipotency exit -...
Nature· 6 days agoA CRISPR/Cas9 screen identities regulators about the transition of pluripotency to totipotency and revealed Mdm2 as a significant negative regulator of totipotency.
Asymptomatic herpes simplex virus brain infection elicits cellular senescence phenotypes in the...
Nature· 5 days agoIdentification of senescence-related markers in the brain and spinal cord of mice with asymptomatic HSV-1 brain infection and animals undergoing experimental autoimmune encephalomyelitis which parallels multiple sclerosis in humans.
Flexible adaptation of task-positive brain networks predicts efficiency of evidence accumulation -...
Nature· 7 days agoAnalyses of fMRI data across two large samples show that people’s cognitive efficiency, as measured by a computational model, is strongly related to the degree to which brain networks involved in cognitive control adapt to task difficulty.
Is Reddit’s WallStreetBets Bullish on ContextLogic Inc. (WISH) Right Now?
Insider Monkey via Yahoo Finance UK· 20 hours agoWe recently compiled a list of the 10 New Stocks Reddit’s WallStreetBets Is Buying. In this article,...
Role of the V2R–βarrestin–Gβγ complex in promoting G protein translocation to endosomes -...
Nature· 2 days agoA V2R–βarrestin–Gβγ complex forms at the plasma membrane and translocates to endosomes. This sheds light on G protein subunit translocation and βarr’s role in sustained signaling.
Genomic sequencing reveals convergent adaptation during experimental evolution in two budding yeast...
Nature· 2 days agoIn this study, the authors retrieve frozen stocks of the K. lactis lineages and reconstruct the evolutionary dynamics of parallel lineages at the genetic level with high throughput sequencing