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    • In this issue - Nature Chemical Biology

      Nature· 19 hours ago

      HIV entry begins when the glycoprotein gp120 binds to the host cell receptor CD4, undergoes a significant conformational change and binds to a second coreceptor. Entry inhibitors have primarily ...

    • Research highlights - Nature Chemical Biology

      Nature· 17 hours ago

      In its inactive state, the SH2 domain of c-Src binds to an intramolecular phosphotyrosine near the C terminus of the protein. In the cell, kinase activity can be switched on by dephosphorylation ...