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Mechanisms of transcriptional memory - Nature Reviews Molecular Cell Biology
Nature· 3 days agoHow can the same gene remember that it is 'off' in one cell lineage and 'on' in another? Studies of how homeotic genes are regulated in Drosophila melanogaster have uncovered a transcriptional ...
Regulation of ion transport proteins by membrane phosphoinositides - Nature Reviews Neuroscience
Nature· 3 days agoMembrane phosphoinositides are important for generating key intracellular second messengers and are also able to directly regulate the activity of membrane proteins. Gamper and Shapiro discuss ...
PTBP1 protects Y RNA from cleavage leading to its apoptosis-specific degradation - Cell Death...
Nature· 3 days agoSome RNAs such as 28S rRNA, U1 small nuclear RNA (snRNA), and Y RNAs are known to be cleaved during apoptosis. The underlying mechanism, functions, and biological significance of RNA degradation ...
Leukaemogenesis: more than mutant genes - Nature Reviews Cancer
Nature· 3 days agoEpigenetic modifications, including DNA methylation and histone modifications, as well as microRNAs, contribute to the development of acute leukaemias. This Review describes the current understanding ...
Studies on somatic recombination in dikaryons of Schizophyllum commune - Heredity
Nature· 3 days agoBuller, A H R. 1931. Researches on Fungi, IV. Longmans Green & Co., London. Google Scholar Crowe, L K. 1960. The exchange of genes between nuclei of a dikaryon. Heredity, 15, 397–405.Article
Vaccination against polio should not be stopped - Nature Reviews Microbiology
Nature· 3 days agoThe reduction in the incidence of poliomyelitis has stalled in the past 7 years, and an urgent re-assessment of the polio-eradication and post-eradication campaign strategies is needed. We propose ...
A point mutation in CD28 distinguishes proliferative signals from survival signals - Nature...
Nature· 3 days agoUpon interaction with its ligand, B7, CD28 becomes phosphorylated on tyrosines. One tyrosine in particular (Y170 in mouse CD28, Y173 in human CD28) has received much attention. This is because ...
Three ways to make a vesicle - Nature Reviews Molecular Cell Biology
Nature· 3 days agoCargo molecules have to be included in carrier vesicles of different forms and sizes to be transported between organelles. During this process, a limited set of proteins, including the coat ...
Neurotrophins are required for nerve growth during development - Nature Neuroscience
Nature· 3 days agoAlthough the requirement of neurotrophins for the prevention of cell death in the peripheral nervous system is well established, their physiological involvement in nerve growth is still unclear ...
Functional Studies of the T295M Mutation Causing Glut1 Deficiency: Glucose Efflux Preferentially...
Nature· 3 days agoGlucose transporter type 1 (Glut1) deficiency syndrome (Glut1 DS, OMIM: #606777) is characterized by infantile seizures, acquired microcephaly, developmental delay, hypoglycorrhachia (CSF glucose ...