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Leveraging the full power of T cells to fight solid tumors
Nature· 2 days agoImmatics is a clinical-stage biopharmaceutical company at the forefront of the discovery and development of T cell–based immunotherapies to treat cancer. Its mission is to ...
Death shapes life - Nature Reviews Molecular Cell Biology
Nature· 2 days agoA little over two years ago, Guido Kroemer, Josef Penninger and collaborators cloned and characterized apoptosis-inducing factor (AIF), a mitochondrial factor released in response to death-triggering ...
Functional genomics at single-cell resolution
Nature· 2 days agoCombining CRISPR screening with single-cell RNA sequencing, Vienna-based Aelian Biotechnology has developed a new discovery tool for functional genomics. It enables biotech ...
Percentage of Binucleate Cells in the Livers of Adult Rats - Nature
Nature· 2 days agoSEVERAL workers have suggested that the percentage of binucleate cells seen in histological sections is not a true measure of the percentage of such cells in the liver. The cells of the liver ...
From the editors - Nature Reviews Molecular Cell Biology
Nature· 2 days agoStudying the movements of single cells has enabled great advances in our understanding of the general mechanisms that underlie cell migration. Effective cell</ ...
Will cells as cinema sell? - Nature Cell Biology
Nature· 2 days agoExploring the Living CellThis lively film produced by the developmental biologist Christian Sardet is laid out in five sections. The first is a historical account of the cell
Disassociation of Heart Cells by Collagenase - Nature
Nature· 2 days agoTHE disassociation of cells from various parent tissues by digestion with trypsin has been often applied by workers on tissue cultures1–3. There are, however, several defects in the trypsinization ...
Spotlight Therapeutics’ cell-specific in vivo gene editing platform, TAGE, takes center stage
Nature· 2 days agoWhile CRISPR-based therapeutics are showing proof-of-concept in the clinic, in vivo gene editing with cell-type specificity remains a major hurdle for the field. San Francisco ...
The AKT inhibitor AZD5363 elicits synthetic lethality in ARID1A-deficient gastric cancer cells via...
Nature· 1 day agoA synthetic lethality between loss of ARID1A expression and AKT inhibition by AZD5363 was validated in both GC cell model system and xenograft model. Mechanistically, AZD5363 ...
Regulation and crosstalk - Nature Reviews Molecular Cell Biology
Nature· 2 days agoRichardson and colleagues had previously noted that loss of function of the tumour suppressor Lethal (2) giant larvae (L(2)GL) in the developing eye of Drosophila melanogaster results in aberrant ...
