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Cytotoxicity Is Predicted by Unbound and Not Total Bilirubin Concentration - Pediatric Research
Nature· 4 days agoAlthough it has been suggested that the unbound, free, (Bf) rather than total (BT) bilirubin level correlates with cell toxicity, direct experimental evidence supporting this conclusion is limited ...
The Probiotic Lactobacillus GG may Augment Intestinal Host Defense by Regulating Apoptosis and...
Nature· 4 days agoNecrotizing enterocolitis (NEC) remains a leading cause of morbidity and mortality in preterm infants. Although its pathogenesis is poorly understood, inappropriate apoptosis of the mucosal ...
McArdle disease: what do neurologists need to know? - Nature Reviews Neurology
Nature· 4 days agoMcArdle disease (also known as glycogen storage disease type V) is a pure myopathy caused by an inherited deficit of myophosphorylase, the skeletal muscle isoform of the enzyme glycogen phosphorylase ...
Mechanisms Mediating Reduced Responsiveness of Neonatal Neutrophils to Lipoxin A4 - Pediatric...
Nature· 4 days agoLipoxin A4 is an eicosanoid that plays a key role in the resolution of neutrophilic inflammation. In these studies, we investigated the hypothesis that responses to lipoxin A4 are impaired in ...
Inflammation at Birth is Associated With Subnormal Development in Very Preterm Infants - Pediatric...
Nature· 4 days agoPreterm birth carries a risk for impaired developmental outcome. We have previously described an association between increased levels of proinflammatory cytokines during the first 72 postnatal ...
Procalcitonin in Children with Escherichia coli O157:H7 Associated Hemolytic Uremic Syndrome -...
Nature· 4 days agoShiga toxin producing Escherichia coli (STEC) are noninvasive enteric pathogens that may cause hemorrhagic colitis (HC) and diarrhea-associated hemolytic uremic syndrome (D+ HUS). We hypothesized ...
End-tidal Carbon Monoxide Levels in Prematurely Born Infants Developing Bronchopulmonary Dysplasia -...
Nature· 4 days agoBronchopulmonary dysplasia (BPD) is associated with an early inflammatory response that persists after the first week of life. Inflammatory mediators can induce hemoxygenase-1 with a consequent ...
Phenylethanolamines inhibit NMDA receptors by enhancing proton inhibition - Nature Neuroscience
Nature· 4 days agoThe phenylethanolamines, ifenprodil and CP-101,606, are NMDA receptor antagonists with promising neuroprotective properties. In recombinant NMDA receptors expressed in Xenopus oocytes, we found ...
Generation of cerebellar granule neurons in vivo by transplantation of BMP-treated neural progenitor...
Nature· 4 days agoCerebellar granule neurons, the most abundant class of CNS neurons, have a critical role in cerebellar function. Granule neurons are generated at the dorsal border of the mesencephalon and metencephalon ...
Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes - Nature...
Nature· 4 days agoLow oxygen tension influences tumor progression by enhancing angiogenesis; and histone deacetylases (HDAC) are implicated in alteration of chromatin assembly and tumorigenesis. Here we show ...