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Common Variable Immunodeficiency - Pediatric Research
Nature· 12 hours agoThe disorder is defined principally by characteristic infection susceptibility with hypogammaglobulinemia and impaired-specific antibody response. Several recent large registry-based studies ...
Plasma Citrulline Concentration Reflects Enterocyte Mass in Children With Short Bowel Syndrome -...
Nature· 12 hours agoThe energy supplied by parenteral nutrition (PN), served to assess intestinal failure severity. Plasma citrulline at inclusion showed a positive correlation with residual short bowel length.
Developmental Changes in Brainstem Neurons Regulating Lower Airway Caliber - Pediatric Research
Nature· 12 hours agoPremature infants are at risk for lower airway obstruction; however, maturation of reflex pathways regulating lower airway patency is inadequately studied. We hypothesized that postnatal maturation ...
Protein modules that manipulate histone tails for chromatin regulation - Nature Reviews Molecular...
Nature· 4 days agoHistones are the predominant protein components of chromatin and are subject to specific post-translational modifications that are correlated with transcriptional competence ...
CCT6A promotes cell proliferation in colon cancer by targeting BIRC5 associated with p53 status -...
Nature· 3 days agoCurrently, the mechanism underlying CCT subunits in cancer progression is incompletely understood. Based on data analysis, the expression of CCT subunit 6 A (CCT6A) is found higher than the ...
Cytotoxicity Is Predicted by Unbound and Not Total Bilirubin Concentration - Pediatric Research
Nature· 4 days agoAlthough it has been suggested that the unbound, free, (Bf) rather than total (BT) bilirubin level correlates with cell toxicity, direct experimental evidence supporting this ...
End-tidal Carbon Monoxide Levels in Prematurely Born Infants Developing Bronchopulmonary Dysplasia -...
Nature· 4 days agoBronchopulmonary dysplasia (BPD) is associated with an early inflammatory response that persists after the first week of life. Inflammatory mediators can induce hemoxygenase-1 with a consequent ...
Procalcitonin in Children with Escherichia coli O157:H7 Associated Hemolytic Uremic Syndrome -...
Nature· 4 days agoPCT was correlated with serum concentrations of lipopolysaccharide (LPS)-binding protein and serum levels of alanine aminotransferase. Using two separate sets of real-time ...
The AKT inhibitor AZD5363 elicits synthetic lethality in ARID1A-deficient gastric cancer cells via...
Nature· 3 days agoGastric cancer (GC) is a deadly disease with poor overall survival and limited therapeutic options. Genetic alterations such as mutations and/or deletions in chromatin remodeling gene AT-rich ...
Low-Dose Lipopolysaccharide Selectively Sensitizes Hypoxic Ischemia-Induced White Matter Injury in...
Nature· 4 days agoLittle is known about roles of inflammation and hypoxic ischemia (HI) in the generation of neuroinflammation and damage of blood-brain barrier (BBB) in the white matter (WM) that displays regional ...