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Precision drug delivery to the central nervous system using engineered nanoparticles - Nature...
Nature· 6 days agoThe development of therapeutics for central nervous system disorders suffers from high failure rates owing to poor blood–brain barrier penetration and lack of targeted delivery. This Review ...
Ginsenoside Rg1 mitigates cerebral ischaemia/reperfusion injury in mice by inhibiting autophagy...
Nature· 4 days agoReperfusion injury, which is distinct from ischaemic injury, occurs when blood flow is restored in previously ischaemic brain tissue, further compromising neurons and other cells and worsening ...
Why so slow? Models of parkinsonian bradykinesia - Nature Reviews Neuroscience
Nature· 4 days agoThere are a number of models that have attempted to explain why people with Parkinson disease move slowly. In this Perspective, Williams identifies the inconsistencies in these models and suggests ...
E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal...
Nature· 6 days agoMitochondrial dysfunction plays a pivotal role in the pathogenesis of Parkinson’s disease (PD). As a mitochondrial governor, voltage-dependent anion channel 1 (VDAC1) is critical for cell survival ...
High-precision object detection network for automate pear picking - Scientific Reports
Nature· 3 days agoTo address the urgent need for agricultural intelligence in the face of increasing agricultural output and a shortage of personnel, this paper proposes a high precision object detection network ...
Zinc mediates control of nitrogen fixation via transcription factor filamentation - Nature
Nature· 5 days agoZinc acts as a second messenger in root nodules and regulates nitrogen homeostasis by controlling the transition between the active state and the inactive filamentous state of the novel transcriptional regulator FIXATION UNDER NITRATE (FUN).
Wearable sensor-based quantitative gait analysis in Parkinson’s disease patients with different...
Nature· 5 days agoGait impairments are among the most common and disabling symptoms of Parkinson’s disease and worsen as the disease progresses. Early detection and diagnosis of subtype-specific gait deficits ...
Exploiting the Fc base of IgG antibodies to create functional nanoparticle conjugates - Scientific...
Nature· 4 days agoThe structures of the Fc base of various IgG antibodies have been examined with a view to understanding how this region can be used to conjugate IgG to nanoparticles. The base structure is found ...
Regulate surging tourism in Antarctic, treaty partners say
Nature· 6 days agoEnvironmental and biosecurity concerns are mounting in the frozen continent
Peak response regularization for localization - Scientific Reports
Nature· 3 days agoDeep convolutional neural networks approaches often assume that the feature response has a Gaussian distribution with target-centered peak response, which can be used to guide the target location ...