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Determining the quantitative accuracy of cDNA microarrays - Nature Genetics
Nature· 3 days agoTrent, Paul S. Meltzer & Michael Bittner Authors Gerald Gooden View author publications You can also search for this author in PubMed Google Scholar David Morse View author ...
Facile metabolic reprogramming distinguishes mycobacterial adaptation to hypoxia and starvation:...
Nature· 6 days agoA multi-omics comparison of the mycobacterial response to hypoxia and starvation reveals that distinct differences in fatty acid and cholesterol metabolism lead to the same non-replicating, drug-tolerant persistence phenotype.
Lipopolysaccharide Exposure Modifies High Tidal Volume Ventilation-Induced Proinflammatory Mediator...
Nature· 7 days agoInfection/inflammation and mechanical ventilation have both independently been shown to increase cytokine/chemokine levels in lung tissue and blood samples of premature patients. Little is known ...
Split intein-mediated protein trans-splicing to express large dystrophins - Nature
Nature· 5 days agoA method is developed for expressing large dystrophins to enhance muscle function in mouse models of muscular dystrophy, with potential clinical benefits for numerous disorders caused by mutations ...
Baseline Values of Candidate Urine Acute Kidney Injury Biomarkers Vary by Gestational Age in...
Nature· 6 days agoAcute kidney injury (AKI) is common in premature infants and is associated with poor outcomes. Novel biomarkers can detect AKI promptly. Because premature infants are born with underdeveloped ...
Molecular subtypes explain lupus epigenomic heterogeneity unveiling new regulatory genetic risk...
Nature· 6 days agoThe heterogeneity of systemic lupus erythematosus (SLE) can be explained by epigenetic alterations that disrupt transcriptional programs mediating environmental and genetic risk. This study ...
Selenoprotein W modulates tau homeostasis in an Alzheimer’s disease mouse model - Communications...
Nature· 5 days agoA study shows that SELENOW binds tau and promotes its degradation via the ubiquitin‒proteasome system. SELENOW deficiency causes synaptic defects and memory deficits in mice, while overexpression ...
Using clusterProfiler to characterize multiomics data - Nature Protocols
Nature· 5 days agoclusterProfiler is a tool for characterizing and visualizing omics data. The example procedures show integration of metabolomics and metagenomics analyses, characterization of transcription factors and annotation of cells in single-cell studies.
Host Genetic Determinants of Human Immunodeficiency Virus Infection and Disease Progression in...
Nature· 7 days agoIncreasing data support host genetic factors as an important determinants of human immunodeficiency virus type-1 (HIV-1) susceptibility, mother-to-child transmission (MTCT), and disease progression ...
Therapy Insight: what nephrologists need to know about primary vesicoureteral reflux - Nature...
Nature· 7 days agoVesicoureteral reflux is a prevalent disease commonly encountered by primary pediatricians, pediatric nephrologists and pediatric urologists. Few issues in pediatrics generate as much controversy ...