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Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human...
Nature· 6 days agoThe mechanisms underlying human cell diversity are unclear. Here the authors provide a single-cell epigenome map of human neural organoid development and dissect how epigenetic changes control ...
The landscape of RNA-chromatin interaction reveals small non-coding RNAs as essential mediators of...
Nature· 2 days agoRNA constitutes a large fraction of chromatin. Spatial distribution and functional relevance of most of RNA-chromatin interactions remain unknown. We established a landscape analysis of RNA-chromatin ...
Synthesis and biochemical characterization of naphthoquinone derivatives targeting bacterial...
Nature· 5 days agoWaldiomycin is an inhibitor of histidine kinases (HKs). Although most HK inhibitors target the ATP-binding region, waldiomycin binds to the intracellular dimerization domain (DHp domain) with ...