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US Fighter jets scrambled as Russian and Chinese bombers spotted over Alaska
Daily Telegraph· 4 days agoNathan Beauchamp-Mustafaga, a policy researcher at the Rand Corporation who specialises in Chinese...
Deubiquitinase USP9x regulates the proline biosynthesis pathway in non-small cell lung cancer - Cell...
Nature· 22 hours agoMetabolic rewiring has been recognized as a hallmark of malignant transformation, supplying the biosynthetic and energetic demands for rapid cancer cell proliferation and tumor progression.
Template-assisted covalent modification underlies activity of covalent molecular glues - Nature...
Nature· 22 hours agoCharacterization of DCAF16-based BRD4 molecular glue degraders revealed a trans-labeling mechanism termed ‘template-assisted covalent modification’, which opens a new path for proximity-driven pharmacology.
Nucleolytic processing of abasic sites underlies PARP inhibitor hypersensitivity in ALC1-deficient...
Nature· 3 days agoLoss of Amplified in Liver Cancer 1 (ALC1) has been shown to confer PARP inhibitor hypersensitivity in BRCA-mutant cells. Here, the authors show that in ALC1-deficient BRCA-mutant cells, APE1 ...