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Ginsenoside Rg1 mitigates cerebral ischaemia/reperfusion injury in mice by inhibiting autophagy...
Nature· 1 day agoReperfusion injury, which is distinct from ischaemic injury, occurs when blood flow is restored in previously ischaemic brain tissue, further compromising neurons and other cells and worsening ...
Exploiting the Fc base of IgG antibodies to create functional nanoparticle conjugates - Scientific...
Nature· 1 day agoThe structures of the Fc base of various IgG antibodies have been examined with a view to understanding how this region can be used to conjugate IgG to nanoparticles. The base structure is found ...
Precision drug delivery to the central nervous system using engineered nanoparticles - Nature...
Nature· 3 days agoThe development of therapeutics for central nervous system disorders suffers from high failure rates owing to poor blood–brain barrier penetration and lack of targeted delivery. This Review ...
E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal...
Nature· 3 days agoMitochondrial dysfunction plays a pivotal role in the pathogenesis of Parkinson’s disease (PD). As a mitochondrial governor, voltage-dependent anion channel 1 (VDAC1) is critical for cell survival ...
Neural connectivity patterns explain why adolescents perceive the world as moving slow -...
Nature· 6 days agoAn EEG study using event segmentation theory found adolescents segment movies into fewer, longer episodes than adults. Differences in neural communication patterns between brain regions explain why younger people perceive the world as moving slower.
Circadian rapid eye movement sleep expression is associated with brain microstructural integrity in...
Nature· 6 days agoThis study highlights the circadian regulation of rapid eye movement sleep as a neurophysiological correlate of subtle brain microstructural changes in key brain regions sensitive to aging and involved in sleep-wake regulation.
No CRISPR: oddball ‘jumping gene’ enzyme edits genomes without breaking DNA
Nature· 1 day agoA programmable RNA that bridges a genetic donor and a target could herald a safer and more flexible...
Zinc mediates control of nitrogen fixation via transcription factor filamentation - Nature
Nature· 2 days agoZinc acts as a second messenger in root nodules and regulates nitrogen homeostasis by controlling the transition between the active state and the inactive filamentous state of the novel transcriptional regulator FIXATION UNDER NITRATE (FUN).
‘Epigenome editor’ silences gene that causes deadly brain disorders
Nature· 1 day agoPrion diseases are caused by misfolded proteins, but a new tool can stop them forming in mice.
Probing electrolyte effects on cation-enhanced CO2 reduction on copper in acidic media - Nature...
Nature· 4 days agoCO2 electroreduction is promoted by alkali cations in the electrolyte, but the precise mechanism by which this occurs is not clear. Now in situ infrared spectroscopy and ab initio molecular ...